Reverse Transcriptase Inhibitors in HIV/AIDS Therapy
Reverse Transcriptase Inhibitors in HIV/AIDS Therapy by Gail Skowron is a comprehensive examination of reverse transcriptase inhibitors (RTIs) utilized in the treatment of HIV/AIDS. Published by Humana Press on May 1, 2006, this edition spans 528 pages and is presented in English. The book covers a wide range of topics, including drug discovery, pharmacology, and the development of drug resistance, providing a detailed overview of the role of reverse transcriptase in the viral life cycle.
Readers will find an in-depth analysis of eight nucleoside and nucleotide analogs that have significantly impacted treatment history, as well as discussions on toxicity and resistance associated with these drugs. The text also explores three non-nucleoside RTIs, their pharmacokinetics, and comparative clinical efficacy. Additionally, it addresses new RTIs currently under development and examines the effects of approved agents on treatment outcomes, particularly concerning the prevention of mother-to-child transmission of HIV/AIDS in developing regions.
Official synopsis Publisher
A magisterial survey of all aspects of the reverse transcriptase inhibitors (RTIs) used to treat HIV/AIDS, including drug discovery, pharmacology, development of drug resistance, toxicity, and prevention of mother-to-child transmission of HIV/AIDS. The authors synthesize our current understanding of the role of reverse transcriptase in the viral life cycle, describe the discovery and development of eight nucleoside and nucleotide analogs that represent milestones in treatment history, and thoroughly discuss the question of toxicity and resistance to this class of drugs. They also address three non-nucleoside RTIs and their pharmacokinetics and comparative clinical efficacy, new RTIs currently under development, and the impact of approved agents on treatment, in general, and on vertical transmission in the developing world.
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