Psychopharmacogenetics
Psychopharmacogenetics by Philip Gorwood, published by Springer US on April 12, 2006, is a comprehensive exploration of psychiatric disorders and their treatment through the lens of pharmacogenetics. This edition spans 566 pages and is presented in English, addressing the complexities of adult and child psychiatric conditions, including mood disorders, psychosis, substance abuse, and dementia. The book highlights the challenges in developing effective treatments and the need for a deeper understanding of the mechanisms involved in these disorders.
Readers will find an in-depth examination of various psychiatric conditions, focusing on their symptoms, risk factors, and treatment options. The text aims to clarify the relationship between psychotropic drugs and their efficacy, side effects, and underlying mechanisms. By integrating insights from clinical psychiatry, pharmacology, neurobiology, and genetics, this book seeks to make psychopharmacogenetic data more accessible for both clinicians and researchers. It emphasizes the importance of predicting treatment outcomes and improving patient compliance, ultimately aiming to enhance the medical and economic management of psychiatric disorders.
Official synopsis Publisher
Adult and child psychiatric disorders, including mood disorders, psychosis, substance abuse, and dementia, represent a large source of disability in the general population. The urgency to develop new treatments that may have better efficacy and tolerance is explained by the fact that none of the treatments currently available can be considered completely satisfying. Several reasons underlie this relative failure, such as, for example, (1) lack of knowledge of the mechanisms involved, (2) heterogeneity of most psychiatric disorders (that have good inter-rater validity but weak relationship with specific neurobiological mechanisms), (3) variable tolerance that leads to poor compliance, and (4) insufficient prediction for a specific treated patient of the efficacy, side effects, and outcome associated with the prescribed treatments.
Furthermore, from an economical point of view, psychiatric disorders are now the most expensive disorders to treat. The costs associated with mental illnesses, which constitute a significant percentage of the total direct health care costs, are currently estimated above $100 billion (USD), representing $1,605 per person per year in the U.S. (9% of the gross national product).
Prediction of efficacy, prevention of major side effects, and selection of the most appropriate treatment should thus have major medical and economical impacts. The pharmacogenetics devoted to psychotropic drugs (psychopharmacogenetics) will help to further develop these points.
The psychopharmacogenetic field represents an important area of research that is based on various specialties including clinical psychiatry, pharmacology, neurobiology and genetics. However, data issued from such relevant investigations are frequently, for clinicians as for scientists, rather obscure and/or scattered.
In this book, the basic and advanced knowledge on psychiatric disorders will be provided for non-clinicians: What is schizophrenia? What are the risk factors? What are the core symptoms? How is it treated? What are the efficacy and side effects of the available treatments and their mechanisms? Are there already some psychopharmacogenetic data useful in clinical practice?
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