The Quest for Cortisone
The Quest for Cortisone by Thom Rooke, published by Michigan State University Press in April 2012, delves into the groundbreaking discovery of cortisone, a compound that transformed the treatment of rheumatoid arthritis. This 284-page book recounts the journey of “Mrs. G.,” the first patient to receive cortisone, and the remarkable effects it had on her health. The narrative highlights the extensive biochemical research that led to the isolation and synthesis of cortisone, as well as the unexpected side effects that accompanied its use.
Readers will find a detailed exploration of the historical context surrounding cortisone’s development, including the pivotal role of the Mayo Clinic and the contributions of scientists Edward Kendall and Philip Hench, who were instrumental in this medical breakthrough. The book also examines the implications of cortisone’s discovery on clinical trials and the evolution of drug testing, providing insight into the complexities of pharmaceutical advancements. Through its factual recounting, The Quest for Cortisone presents a comprehensive look at a significant chapter in medical history.
Official synopsis Publisher
In 1948, when “Mrs. G.,” hospitalized with debilitating rheumatoid arthritis, became the first person to receive a mysterious new compound―cortisone―her physicians were awestruck by her transformation from enervated to energized. After eighteen years of biochemical research, the most intensively hunted biological agent of all time had finally been isolated, identified, synthesized, and put to the test. And it worked. But the discovery of a long-sought “magic bullet” came at an unanticipated cost in the form of strange side effects. This fascinating history recounts the discovery of cortisone and pulls the curtain back on the peculiar cast of characters responsible for its advent, including two enigmatic scientists, Edward Kendall and Philip Hench, who went on to receive the Nobel Prize. The book also explores the key role the Mayo Clinic played in fostering cortisone’s development, and looks at drugs that owe their heritage to the so-called “King of Steroids.”
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