Genetic Epidemiology Methods and Protocols
Genetic Epidemiology Methods and Protocols by Evangelos Evangelou, published by Springer New York on June 7, 2018, is a comprehensive volume comprising 299 pages. This book presents detailed descriptions of methods and analytical approaches that enhance the understanding of the genome’s relationship to complex diseases. It covers a range of topics, including common and rare genetic variations, gene-gene and gene-environment interactions, and advanced methodologies for synthesizing genome-wide and gene expression data.
Readers will find chapters that guide them through innovative techniques such as associations in the HLA region, family-based designs, Mendelian Randomization, and Copy Number Variation. The volume also addresses the challenges researchers encounter when transitioning from identifying genetic variants to exploring their functional roles and potential drug targets. Written in the established Methods in Molecular Biology series format, each chapter includes introductions to the topics, thorough presentations of methods, and practical tips for troubleshooting common issues.
Official synopsis Publisher
This volume details fast-moving research while providing in-depth descriptions of methods and analytical approaches that are helping to understand the genome and how it is related to complex diseases. Chapters guide the reader through common and rare variation, gene-gene and gene-environment interactions and state-of-the-art approaches for the synthesis of genome-wide and gene expression data. Novel approaches for associations in the HLA region, family-based designs, Mendelian Randomization and Copy Number Variation are also presented. The volume concludes with the challenges researchers face while moving from identifying variants to their functional role and potential drug targets. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, a thorough presentation of methods and approaches and tips on troubleshooting and avoiding known pitfalls.
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