Oxygen Creating a New Paradigm

Oxygen Creating a New Paradigm by Paul L. Marino, published by Wolters Kluwer in 2022, presents a thought-provoking examination of the role of oxygen in human physiology. This first edition, comprising 218 pages, challenges the conventional belief that oxygen is solely beneficial for life. Instead, Dr. Marino argues that oxygen can be a destructive molecule, leading to significant cellular damage and inflammation. The book explores the body’s inherent mechanisms to limit oxygen exposure and the importance of antioxidants in mitigating oxidative harm.
Readers will find a comprehensive discussion on how oxygen interacts with vital cell components and the implications of this relationship for clinical practices, particularly in respiratory therapy and critical care. Dr. Marino delves into the body’s natural operation in low-oxygen environments and critiques the traditional views on oxygen delivery and transport. By proposing an “oxygen-protective” management strategy, this work invites a reevaluation of established medical practices regarding oxygen use, making it a relevant resource for professionals in medical and life sciences.
Official synopsis Publisher
This unique work from acclaimed author Dr. Paul Marino (Marino’s The ICU Book, The Little ICU Book) challenges the traditional notion that the human body thrives on oxygen, and that promoting tissue oxygenation is necessary for promoting life. This concept fails to recognize that oxygen is a destructive molecule that also damages the human body. Instead of welcoming oxygen, the human body limits exposure of the tissues to oxygen, and employs an army of chemical antioxidants to combat the damaging effects of oxygen. This “oxygen protective” human design represents a new paradigm for the relationship between oxygen and human survival, and it has important implications for the excessive and unregulated use of oxygen in clinical practice. Dr. Marino’s book includes the following relevant features:
- Describes how oxygen and its reactive derivatives can damage vital cell components, and how oxygen plays a pivotal role in the damaging effects of inflammation, radiation, and aging.
- Challenges the traditional notion that oxygen delivery is the principal function of the cardiorespiratory system, and that oxygen transport is the principal function of red blood cells and hemoglobin.
- Demonstrates how the tissues normally operate in an oxygen-poor environment (which limits the risk of oxidative damage), and how the body counteracts attempts to increase tissue oxygenation.
- Describes the body’s use of protective antioxidants, and shows how failure to maintain this antioxidant protection makes oxygen inhalation an unrecognized source of harm.
- Reveals the lack of evidence that cellular hypoxia is a final common pathway for cell death, and proposes that oxygen itself is responsible for the death of aerobic organisms.
- Proposes a new management strategy that is “oxygen-protective” rather than “oxygen-promoting.”
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